Shreesh Sammi, PhD
- Assistant Professor of Translational Neuroscience
- Department of Translational Neuroscience
- Michigan State University College of Human Medicine
- Grand Rapids Research Center
- 400 Monroe Ave NW, Grand Rapids, MI 49503
- Phone: 616.234.0957
- sammishr@msu.edu
Biography
Dr. Sammi received his B.S. from M.L.N. College, Yamuna Nagar (Kurukshetra University). He obtained his master’s degree in Biotechnology from S.B.S.P.G.I. Dehradun (H.N.B. Garhwal University), and then went to Central Drug Research Institute Lucknow (Jawaharlal Nehru University) for his PhD in Life Science. Post PhD, Dr. Sammi briefly worked at the Central Institute of Medicinal and Aromatic Plants, Lucknow. He did his postdoctoral training with Dr. Jason R. Cannon at Purdue University. His hobbies include motorcycle riding, woodworking, and cooking.
Education
| Institution | Field of Study | Degree Earned | Year |
|---|---|---|---|
| Purdue University, Lafayette IN | Neurotoxicity of dietary and environmental factors | Postdoctoral Research | 2016-2023 |
| Jawaharlal Nehru University (Central Drug Research Institute), India | Life Science | PhD | 2015 |
| H. N. B. Garhwal University, India | Biotechnology | MS | 2008 |
| Kurukshetra University, India | Biotechnology, Chemistry, and Zoology | BS | 2006 |
Research Interests
Dr. Sammi’s focuses on gaining insights into the mechanisms involved in neurodegenerative disorders, particularly Parkinson's disease, Amyotrophic Lateral Sclerosis, and Alzheimer's disease. He is working towards discerning the mechanism of toxicants instigated disease progression and identifying possible targets for intervention. Utilizing C. elegans and in vitro models, he has been conducting research pertaining to investigating the underlying mechanism and evaluation of the therapeutic potential of synthetic and natural compounds. He is especially interested in identifying the effects and underlying causes of Polyfluoro-alkyl substances (PFAS) associated neurotoxicity. His further interests entail studies aimed at discerning the role of Optineurin in pathologies related to Amyotrophic Lateral Sclerosis, Alzheimer's, and Parkinson's disease.
Technical Expertise
- C. elegans culture
- Neurotoxic and Neurobehavioral assessment.
- Flow-cytometry
- qPCR
- Immunoblotting
- Immunohistochemistry
- Enzyme assays
- Cell Free assays
- Bioenergetics
- Cell culture
- Fluorescence microscopy
- 2D Gel Electrophoresis
- Pharmacological assessment in rodents (Anticancer, Anti-inflammatory, Analgesic, Antipyretic)